As for making a difference in my game play, the answer is a yes* with a * for me. While I understood the reasoning for gaming mice, I never really thought much about it as I never really considered myself a serious gamer. That changed the last 18 months as I have been pretty much a regular Call of Duty 4 gamer, and as of late, I took competition a little more seriously. What this essentially means is that any sort of edge I could find, I would at least give it a try. From PC upgrades to a change in Internet provider, the last issues I seemed to have were my input devices. As I had been using the Microsoft Wireless Desktop 7000 for a while, one issue I have always had was the freezing (where my wireless connection would drop) on occasion. With the NZXT Avatar, this problem was obviously gone (I also replaced my keyboard with a corded one).