In this review I will describe a very unusual looking mouse from Hippus, named HandshoeMouse. This peripheral is build with hand relaxation in mind, and not for gaming purposes. This mouse was developed by Hippus together with Erasmus MC, Erasmus University Hospital Rotterdam, and it is meant to reduce complaints ( excessive muscle tension in neck, shoulders, arms and hands), as well as the risk or RSI (Repetitive Strain Injury).