DriveCleanup does what you could do manually in the Windows Device Manager - remove all currently non-present USB, Disks, CDROMs, Floppies, Storage Volumes and WPD devices from the device tree.

DriveCleanup does what you could do manually in the Windows Device Manager - remove all currently non-present USB, Disks, CDROMs, Floppies, Storage Volumes, and WPD devices from the device tree.

Removes from the device tree non present:

USB hubs
USB mass storage devices
Disk devices
CDROM devices
Floppy devices
Storage Volumes
WPD devices (Vista, Win7, Win8 and higher only)

and their registry items under

HKEY_LOCAL_MACHINESYSTEMMountedDevices
HKEY_LOCAL_MACHINESYSTEMCurrentControlSetEnum
HKEY_LOCAL_MACHINESYSTEMCurrentControlSetControlUsbFlags
HKEY_LOCAL_MACHINESYSTEMCurrentControlSetControlDeviceClasses
HKEY_CURRENT_USERSoftwareMicrosoftWindowsCurrentVersionExplorerMountPoints2
HKEY_CURRENT_USERSoftwareMicrosoftWindowsCurrentVersionExplorerMountPoints2CPCVolume

Disk, CDROM, and Floppy devices are removed only if they are USB or if they have a removal policy > 1 (EXPECT_ORDERLY_REMOVAL or EXPECT_SURPRISE_REMOVAL).

Similar:
How to Show or Hide the Safely Remove Hardware Icon
How to Diagnose USB Problems
How to Turn On or Off USB Issue Notifications in Windows 10

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