AutoHotkey provides you with a fast, scriptable desktop automation tool with hotkeys.

Easily Automate almost anything you want: Send keystrokes & mouse clicks; launch programs and documents; work with the clipboard, registry, & sound card settings. In addition to its automation features described below, it excels at hotkeys, able to make virtually any keyboard key, mouse/joystick button, or combination into a fast hotkey.

It can also individually disable or override Windows' shortcut keys, such as Win+R/E. It may also help alleviate RSI (repetitive strain injury); for example, it can create substitutes for Alt-Tab using keys, mouse wheel, buttons - the choice is yours.