If using a tool in the operating system is not your bag, ASUS has a set of overclocking settings in the BIOS called CPU Level Up. In this tool you get three levels of core clock speed overclocking: 4.2GHz, 4.4GHz and 4.6GHz. Each level changes all of the settings in the BIOS to facilitate a stable overclock as long as your cooling can handle the load. Something it could not do for me with the 4.6GHz profile. Even when using a dedicated water loop the CPU would throttle when running Prime 95 using the 4.6GHz due to the voltage applied by the tool. The results with the 4.2GHz and 4.4GHz profiles were perfectly stable and kept thermals in check. Should you choose to go full tilt on CPU speed and decide sub zero cooling is the way to go, ASUS provides a wide selection of pre-programmed profiles in the BIOS. Using water cooling you can stick to manual tuning for the best 24/7 results.