Hardware.Info posted a review on the ASRock X299E-ITX/ac
A quote from the article:
While Intel's socket 2066 is not as large as the Threadripper-socket it is still special that ASRock can make a mini-ITX motherboard for it. On this unique board of 17 by 17 centimeters you can use an 18-core processor. The ASRock X299E-ITX/ac offers X299 in ITX format: a good idea or the ultimate concession?ASRock X299E-ITX/ac Review
High-end platforms are usually a good option for those who have more money to spend. The difference with the regular processor series is mainly in the quantity: some more cores, some more memory channels, some more PCI-Express lanes and so on. ITX therefore does not seem to be the most suitable format for an X299 motherboard- the vast majority of the boards for this platform are ATX format or even bigger, but ASRock still succeeded in manufacturing an ITX board.